Incorporating Inheritance into Models for Understanding Ventilatory Behavior

Kingman P. Strohl; Shyam Subramanian; Fang Han; Karem Principe; Theodore E. Dick

doi:10.1055/s-2001-12793

Sleep and Breathing, Table of Contents

Sleep Breath 2001; 05(1): 047-052
DOI: 10.1055/s-2001-12793

EMERGING RESEARCH

Incorporating Inheritance into Models for Understanding Ventilatory Behavior

Kingman P. Strohl, Shyam Subramanian, Fang Han, Karem Principe, Theodore E. Dick

Department of Medicine, Louis Stokes VA Medical Center, and Case Western Reserve University, Cleveland, Ohio

Abstract

ABSTRACT

Ventilation and its components (frequency and tidal volume) appear to be determined to a significant extent by inheritance. Gene manipulation, gene identification, and functional genomics now offer powerful tools to identify the strength and mode of inheritance for ventilatory behavior under steady-state and non-steady-state conditions, in health and in disease. Conscious integration of genetic principles into existing explanatory models may increase the likelihood of detecting traits that correlate with protein systems responsible for the structures and the functional components of respiration.

KEYWORD

Modeling - quantitative genetics - respiration

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References

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